Database containing mammalian elimination half-lives now published
The first version of the mammalian toxicokinetic database is now published. This database contains elimination half-life values for around 1 400 substances collected from publications and publicly available studies. The data was collected by Norwegian Institute of Public Health (NIPH) together with ECHA during 2016-2020.
In fact, the elimination half-lives in mammals, including humans, have been proposed as a potential complementary metric to expand the assessment of bioaccumulative properties to cover air-breathing organisms. To explore the possibilities of using such data in bioaccumulation assessment and predictions, human and terrestrial mammalian elimination half-life data has been collected along with physiochemical data and parameters. The database will facilitate looking up toxicokinetic data and finding respective studies.