Those include two new Test Guidelines on in vitro methods for fish hepatic clearance (<link https: www.oecd-ilibrary.org environment test-no-319a-determination-of-in-vitro-intrinsic-clearance-using-cryopreserved-rainbow-trout-hepatocytes-rt-hep_9789264303218-en _blank guideline>TG 319A and <link https: www.oecd-ilibrary.org environment test-no-319b-determination-of-in-vitro-intrinsic-clearance-using-rainbow-trout-liver-s9-sub-cellular-fraction-rt-s9_9789264303232-en _blank guideline>TG 319B) that can be used to improve in silico predictions of the test chemical bioaccumulation in fish.

Important updates to existing Test Guidelines encompass the inclusion of endocrine-related endpoints in <link https: www.oecd-ilibrary.org environment test-no-408-repeated-dose-90-day-oral-toxicity-study-in-rodents_9789264070707-en _blank guideline>TG 408 (90-d repeated dose toxicity study) and <link https: www.oecd-ilibrary.org environment test-no-414-prenatal-development-toxicity-study_9789264070820-en _blank guideline>TG 414 (Developmental toxicity study); also Test Guidelines in the area of eye irritation and skin sensitisation have been revised to either improve predictivity of the existing method (<link https: www.oecd-ilibrary.org environment test-no-438-isolated-chicken-eye-test-method-for-identifying-i-chemicals-inducing-serious-eye-damage-and-ii-chemicals-not-requiring-classification-for-eye-irritation-or-serious-eye-damage_9789264203860-en _blank guideline>TG 438 – isolated chicken eye method) or include similar methods to those already existing (me-too methods in <link https: www.oecd-ilibrary.org environment test-no-442b-skin-sensitization_9789264090996-en _blank guideline>TG 442B, <link https: www.oecd-ilibrary.org environment test-no-442d-in-vitro-skin-sensitisation_9789264229822-en _blank guideline>TG 442D, <link https: www.oecd-ilibrary.org environment test-no-492-reconstructed-human-cornea-like-epithelium-rhce-test-method-for-identifying-chemicals-not-requiring-classification-and-labelling-for-eye-irritation-or-serious-eye-damage_9789264242548-en _blank guideline>TG 492) ensuring more readily usable practical matter by members and <link http: www.oecd.org env ehs mutualacceptanceofdatamad.htm _blank acceptance of data>Mutual Acceptance of Data (MAD) adhering countries.

Further information can be found on <link http: www.oecd.org chemicalsafety testing oecdguidelinesforthetestingofchemicals.htm _blank>OECD website.